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Pathways  Adhesion

Adhesion  
Click To View Pathway Activation of cAMP-dependent protein kinase, PKA
G-protein coupled receptors
Click To View Pathway Adhesion and Diapedesis of Granulocytes
Cell adhesion is a fundamental feature of multicellular organisms including their defense mechanisms. In the later case in mammals, leukocytes play central role. They bind bacteria, parasites, viruses, tumor cells etc. Furthermore, their interactions ...
Click To View Pathway Adhesion and Diapedesis of Lymphocytes
Cell adhesion is a fundamental feature of multicellular organisms including their defense mechanisms. In the later case in mammals, leukocytes play central role. They bind bacteria, parasites, viruses, tumor cells etc. Furthermore, their interactions ...
Click To View Pathway Adhesion Molecules on Lymphocyte
B cell and T cell lymphocytes interact with a variety of cells as part of their immune function, circulating and homing in on specific stimuli in tissues like inflammatory signals. The interaction of lymphocytes with other cell types like vascular en ...
Click To View Pathway AKT Signaling Pathway
Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cytoplasm from the cell surface. PIP3 signals activates the kinase PDK1, 3-phosphoinositide-dependent p ...
Click To View Pathway Basic Mechanisms of SUMOylation
Like ubiquitin, SUMO (small ubiquitin-related modifier) proteins are small protein tags that are conjugated to proteins to modify their function. The ubiquitin system tags proteins for degradation by the proteosome (see Proteosome pathway) but SUMO ...
Click To View Pathway CD226 Adhesion Complex
Successful immunological response is related to clustering of the T cell integrin lymphocyte function-associated antigen-1 (LFA-1) at specialized regions of intercellular contact. The LFA-1 clustering initiates integrin-mediated adhesion and downstr ...
Click To View Pathway CD44 Signaling Pathway
The CD44 transmembrane cell adhesion protein found in a wide range of cells is the receptor for extracellular hyaluronate and provides the main interaction of some cells with the extracellular matrix. In addition to adhering to the extracellular mat ...
Click To View Pathway Cell to Cell Adhesion Signaling
Interactions between cells responsible for cell to cell adhesion also can communicate signals into the cellular interior, often involving interactions with cytoskeletal elements to produce changes in cell motility, migration, proliferation and shape. ...
Click To View Pathway Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
Activation of the MAPK kinase pathway has been identified as a mechanism that integrins use to regulate gene expression leading to cell shape changes during cell spreading or migration Epithelial cells respond to extracellular matrix (ECM) cause inte ...
Click To View Pathway Erk1/Erk2 Mapk Signaling pathway
The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growth factor receptors and tyrosine kinases activate Ras which in turn activates c-Raf, MEK, and MAP kin ...
Click To View Pathway g-Secretase mediated ErbB4 Signaling Pathway
The HER4/erbB4 receptor tyrosi
Click To View Pathway Inhibition of Cellular Proliferation by Gleevec
The drug Gleevec (also known as imatinib mesylate or STI-571) was approved by the FDA in 2001 for the treatment of CML, chronic myeloid leukemia. While traditional cytotoxic cancer treatments such as chemotherapy or radiation therapy kill all dividi ...
Click To View Pathway Inhibition of Matrix Metalloproteinases
Cellular transformation is accompanied by many cellular changes, including uncontrolled proliferation, loss of the differentiated cell morphology, and invasion of the extracellular matrix. Degradation of the extracellular matrix is a key component o ...
Click To View Pathway Integrin Signaling Pathway
Integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals in response to the extracellular matrix including cellular shape, mobility, and progression through the cell cycle. Integrins do not th ...
Click To View Pathway mCalpain and friends in Cell motility
The mammalian calpain gene family currently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. ( An excellent introduction to the calpain family can be found on a web site created by Valery Thomp ...
Click To View Pathway Migfilin-Mediated Actin Remodeling
Remodeling of the actin cytoskeleton is a critical step in the modulation of the cell shape and migration. Cell-extracellular matrix adhesions are important determinants of the cell morphology. Cell-extracellular matrix adhesion protein complexes ca ...
Click To View Pathway Molecular Architecture of Tight Junctions
Tight junctions (TJs) are domains of occluded intercellular clefts. A very important function of epithelia and endothelia is to separate different compartments within the organism and to regulate the exchange of substances between them. TJs create a ...
Click To View Pathway Molecular Interactions of Integrin-Linked Kinase
Integrin-linked kinase (ILK) is a serine/threonine protein kinase and unique intracellular adaptor that links the cell-adhesion receptors, integrins, structural proteins and growth factors to the actin cytoskeleton and to different of signaling pathw ...
Click To View Pathway Nectin Intercellular Adhesion Complexes
Nectins are cell adhesion, immunoglobulin-like family consisting of at least four members, nectin-1, nectin-2, nectin-3 and nectin-4. All nectins, except nectin-4, have two or three splice variants. Nectins are evolutionary conserved proteins. Nectin ...
Click To View Pathway Regulation of Keratinocyte Migration
Epidermal wound repair requires both keratinocyte migration and laminin 5 deposition over exposed dermal collagen type I. Laminins are heterotrimeric proteins, consisting of a (alpha), b (beta), and g (gamma) subunit chains. Laminin 5 (a3b3g2) is an ...
Click To View Pathway Rho cell motility signaling pathway
RhoA is a small G-protein in the Rho family that regulates cell morphology via actin cytoskeleton reorganization in response to extracellular signals. The majority of RhoA activations is due to disruption of intramolecular autoinhibitory interaction ...
Click To View Pathway Role of Peroxisome Proliferator-Activated Receptor in Inflammation
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors from the nuclear receptor family, originally implicated in the regulation of lipid and glucose homeostasis. In addition, natural and synthetic PPAR activat ...
Click To View Pathway Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration
Migration of cells is involved in essential functions such as development, invasiveness of cancer cells, leukocyte movement toward chemotactic signals, and fibroblast response to injury. Cells can migrate in a specific direction in response to extrac ...
Click To View Pathway The Role Caveolin-1 in Tumour-cell Invasion
During metastasis, changes in the tissue microenvironment allow cancer cells to escape the tumour and disseminate. Epidermal growth factor receptor ( EGFR ) overexpression and downregulation of E-cadherin, disrupt cell–cell interactions. These proces ...
Click To View Pathway The Role of the Cxcr4 Chemokine Receptor and pVHL Tumor Suppressor in Metastasis
The extent of metastasis into other tissues is a key predictor of survival for some types of cancer. The invasion of normal tissues by cancer cells can involve stimulation of chemokine receptors expressed by cancer cells and their ligands expressed ...
Click To View Pathway The SARS-coronavirus Life Cycle
Severe Acute Respiratory Syndrome (SARS) has affected thousands of individuals, causing fever, and pneumonia with a mortality rate estimated at 10-18%. A novel coronavirus has been identified as the cause agent and its genome has been sequenced. Hum ...
Click To View Pathway Trefoil Factors Initiate Mucosal Healing
Maintaining the integrity of the gastrointestinal tract despite the continual presence of microbial flora and injurious agents is essential. Epithelial repair requires restitution and regeneration. During restitution, epithelial cells spread and migr ...
Click To View Pathway TSP-1 Induced Apoptosis in Microvascular Endothelial Cell
As tissues grow they require angiogenesis to occur if they are to be supplied with blood vessels and survive. Factors that inhibit angiogenesis might act as cancer therapeutics by blocking vessel formation in tumors and starving cancer cells. Thrombo ...
Click To View Pathway uCalpain and friends in Cell spread
The mammalian calpain gene family curently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. ( An excellent introduction to the Calpain family can be found on a web site created by Valery Thomp ...
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