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Pathways  Hematopoiesis

Hematopoiesis  
Click To View Pathway ALK in cardiac myocytes
Heart formation is cued by a combination of positive and negative signals from surrounding tissues. Inhibitory signals that block heart formation in anterior paraxial mesoderm include Wnt family members expressed in dorsal neural tube and anti-BMPs ...
Click To View Pathway Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
Ang II binding to AT1-R triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to the Pyk2 and further to the small G protein Rac1 but not Cdc42, although the direct activation of Rac1 by Pyk2 is not proved in this study. ...
Click To View Pathway Band 3-based macrocomplex in the erythrocyte membrane
The erythrocyte anion exchanger (band 3 or AE1) and Rh complexes are associated in the RBC membrane as a single band 3-based macrocomplex. Band 3-based complexes have the potential to signal between the extracellular environment, the cytoskeleton and ...
Click To View Pathway Basophils - from Stem to blood
Click To View Pathway CCR3 signaling in Eosinophils
Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response in inflammation is absent in mice lacking CCR3, indicating the key role of this G protein coupled ...
Click To View Pathway C-Reactive Protein, Apo-B in Lipid Metabolism and Cardiovascular Disease
In addition to the well known markers for risk of cardiovascular disease such as high LDL levels in plasma, other non-traditional markers have emerged as strong indicators of risk, including high levels of C-reactive protein (CRP) and the apolipoprot ...
Click To View Pathway Cytokine Network
Several different cell types coordinate their efforts as part of the immune system, including B cells, T cells, macrophages, neutrophils, basophils and eosinophils. Each of these cell types has a distinct role in the immune system, and communicates w ...
Click To View Pathway Dendritic cells in regulating TH1 and TH2 Development
While T cells and B cells carry out the actions of antigen-specific immune responses, antigen-presenting cells called dendritic cells are required for this to happen. The name of dendritic cells is based on their shape, with activated dendritic cells ...
Click To View Pathway Eosinophils - from Stem to blood
Click To View Pathway EPO Signaling Pathway
Erythropoietin functions to increase the number of red blood cells. Thus, it has found utility as a drug for those needing to replenish erythrocytes for a number of reasons. The signaling mechanism includes multimerization of the receptor upon ligand ...
Click To View Pathway Erythrocyte Differentiation Pathway
Stem cells in the bone marrow produce a variety of hematopoietic cell types from common progenitor cells under the influence of cytokines and growth factors. CFU-GEMM cells are a key intermediate in the differentiation of granulocytes, erythrocytes, ...
Click To View Pathway Hemoglobin's Chaperone
The function of hemoglobin in oxygen transport by red blood cells requires precise assembly of a tetramer of two beta-subunits and two alpha-units. If too many beta-subunits are present, then all tetramers of beta-subunits are formed that bind oxyge ...
Click To View Pathway IL 17 Signaling Pathway
Inflammation is a complex response involving many different cells and signaling molecules, including the secretion of the cytokine IL-17 by activated T cells. IL-17 secretion is restricted to specific subsets of T cells but the receptor for IL-17 is ...
Click To View Pathway Membrane-cytoskeleton connections in erythrocytes
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Cano ...
Click To View Pathway PECAM-1 as a Scaffold for Signaling and Adaptor Molecule
Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kD member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and selected T cell subsets. It is also a major const ...
Click To View Pathway Pertussis toxin-insensitive CCR5 Signaling in Macrophage
The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV infection. One mechanism of signaling by these GPCRs is through activation of Gi signaling. These che ...
Click To View Pathway Platelets - from Stem to blood
Click To View Pathway Regulation of hematopoiesis by cytokines
The process of hematopoesis is regulated by various cytokines. The combination of cytokines stimulates the proliferation and/or differentiation of the various hematopoietic cell types. Bone marrow stromal cells are the major source of hematopoietic ...
Click To View Pathway Regulators of Bone Mineralization
Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth in the interior of membrane-limited matrix vesicles (MVs) and by propagating the crystals onto the collagenous extracellular matrix. Two osteoblast proteins, ...
Click To View Pathway Selective expression of chemokine receptors during T-cell polarization
Chemokine receptors expressed by T helper cells help recruit cells to specific locations based on their chemoattractant ligands. The polarization of T cells into Th1 and Th2 cells is associated with their expression of different subsets of chemokine ...
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