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Pathways  All Pathways
Observe how genes interact in dynamic graphical models. Our online maps depict molecular relationships from areas of active research. In an "open source" approach, this community-fed forum constantly integrates emerging proteomic information from the scientific community. It also catalogs and summarizes important resources providing information for over 120,000 genes from multiple species. Find both classical pathways as well as current suggestions for new pathways.

Acetylation and Deacetylation of RelA in The Nucleus
Actions of Nitric Oxide in the Heart
Activation of cAMP-dependent protein kinase, PKA
Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
Activation of PKC through G protein coupled receptor
Activation of Src by Protein-tyrosine phosphatase alpha
Acute Myocardial Infarction
Adhesion and Diapedesis of Granulocytes
Adhesion and Diapedesis of Lymphocytes
Adhesion Molecules on Lymphocyte
ADP-Ribosylation Factor
Agrin in Postsynaptic Differentiation
Ahr Signal Transduction Pathway
AKAP95 role in mitosis and chromosome dynamics
AKT Signaling Pathway
ALK in cardiac myocytes
Alpha-synuclein and Parkin-mediated proteolysis in Parkinson's disease
Alternative Complement Pathway
Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
Angiotensin-converting enzyme 2 regulates heart function
Anthrax Toxin Mechanism of Action
Antigen Dependent B Cell Activation
Antigen Processing and Presentation
Antisense Pathway
Apoptotic DNA fragmentation and tissue homeostasis
Apoptotic Signaling in Response to DNA Damage
Aspirin Blocks Signaling Pathway Involved in Platelet Activation
ATM Signaling Pathway
Attenuation of GPCR Signaling

B Cell Receptor Complex
B Cell Survival Pathway
B Lymphocyte Cell Surface Molecules
Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression
Basic Mechanisms of SUMOylation
BCR Signaling Pathway
Beta-Oxidation of Fatty Acids
Bioactive Peptide Induced Signaling Pathway
Biosynthesis of Arginine in Bacteria
Biosynthesis of Chorismate in Bacteria and Plants
Biosynthesis of Cysteine from serine in bacteria and plants
Biosynthesis of Cysteine in mammals
Biosynthesis of Glycine and Serine
Biosynthesis of isoleucine
Biosynthesis of leucine
Biosynthesis of Lysine
Biosynthesis of neurotransmitters
Biosynthesis of phenylalanine and tyrosine in bacteria and plants
Biosynthesis of Proline in Bacteria
Biosynthesis of spermidine and spermine
Biosynthesis of sphingolipids
Biosynthesis of threonine and methionine
Biosynthesis of Tryptophan in Bacteria and Plants
Biosynthesis of valine
Blockade of Neurotransmitter Relase by Botulinum Toxin
Bone Remodelling
BRCA1-dependent Ub-ligase activity
BTG family proteins and cell cycle regulation
Bystander B Cell Activation

Ca++/ Calmodulin-dependent Protein Kinase Activation
Cadmium induces DNA synthesis and proliferation in macrophages
Calcium Signaling by HBx of Hepatitis B virus
Cardiac Protection Against ROS
CARM1 and Regulation of the Estrogen Receptor
Caspase Cascade in Apoptosis
Catabolic pathway for asparagine and asparate
Catabolic pathways for alanine, glycine, serine, cysteine, tryptophan, and threonine
Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline
Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine
CBL mediated ligand-induced downregulation of EGF receptors
CCR3 signaling in Eosinophils
CD40L Signaling Pathway
cdc25 and chk1 Regulatory Pathway in response to DNA damage
CDK Regulation of DNA Replication
Cell Cycle: G1/S Check Point
Cell Cycle: G2/M Checkpoint
Cell to Cell Adhesion Signaling
Cells and Molecules involved in local acute inflammatory response
Ceramide Signaling Pathway
Chaperones modulate interferon Signaling Pathway
Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes
Circadian Rhythms
Classical Complement Pathway
Comparison of Beta oxidation in mitochondria and peroxisomes and glyoxysomes
Complement Pathway
Control of Gene Expression by Vitamin D Receptor
Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)
Corticosteroids and cardioprotection
CTCF: First Multivalent Nuclear Factor
CTL mediated immune response against target cells
CXCR4 Signaling Pathway
Cyclin E Destruction Pathway
Cycling of Ran in nucleocytoplasmic transport
Cyclins and Cell Cycle Regulation
Cystic Fibrosis Transmembrane Conductance Regulator And Beta 2 Adrenergic Receptor Pathway
Cytokine Network
Cytokines and Inflammatory Response

D4-GDI Signaling Pathway
Degradation of the RAR and RXR by the proteasome
Dendritic cells in regulating TH1 and TH2 Development
Deregulation of CDK5 in Alzheimers Disease
Dicer Pathway
Double Stranded RNA Induced Gene Expression
Downregulated of MTA-3 in ER-negative Breast Tumors

E2F1 Destruction Pathway
Effects of calcineurin in Keratinocyte Differentiation
EGF Signaling Pathway
Eicosanoid Metabolism
Electron Transport Reaction in Mitochondria
Endocytotic role of NDK, Phosphins and Dynamin
Eph Kinases and ephrins support platelet aggregation
EPO Signaling Pathway
ERľassociated degradation (ERAD) Pathway
Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
Erk1/Erk2 Mapk Signaling pathway
Erythrocyte Differentiation Pathway
Erythropoietin mediated neuroprotection through NF-kB
Estrogen-responsive protein Efp controls cell cycle and breast tumors growth
Eukaryotic protein translation
Extrinsic Prothrombin Activation Pathway

FAS signaling pathway ( CD95 )
Fc Epsilon Receptor I Signaling in Mast Cells
Feeder Pathways for Glycolysis
Fibrinolysis Pathway
fMLP induced chemokine gene expression in HMC-1 cells
Formation of Ketone Bodies from acetyl-CoA
FOSB gene expression and drug abuse
Free Radical Induced Apoptosis
Function of SLRP in Bone: An Integrated View
FXR and LXR Regulation of Cholesterol Metabolism

Gamma-aminobutyric Acid Receptor Life Cycle
GATA3 participate in activating the Th2 cytokine genes expression
Generation of amyloid b-peptide by PS1
Ghrelin: Regulation of Food Intake and Energy Homeostasis
Glycolysis Pathway
G-Protein Signaling Through Tubby Proteins
Granzyme A mediated Apoptosis Pathway
Growth Hormone Signaling Pathway
g-Secretase mediated ErbB4 Signaling Pathway

Hemoglobin's Chaperone
HIV Induced T Cell Apoptosis
HIV-1 defeats host-mediated resistance by CEM15
HIV-I Nef: negative effector of Fas and TNF
Hop Pathway in Cardiac Development
How does salmonella hijack a cell
How Progesterone Initiates Oocyte Membrane
Human Cytomegalovirus and Map Kinase Pathways
Hypoxia and p53 in the Cardiovascular system
Hypoxia-Inducible Factor in the Cardiovascular System

IFN alpha signaling pathway
IFN gamma signaling pathway
IGF-1 Signaling Pathway
IL 17 Signaling Pathway
IL 18 Signaling Pathway
IL 2 signaling pathway
IL 3 signaling pathway
IL 4 signaling pathway
IL 5 Signaling Pathway
IL 6 signaling pathway
IL-10 Anti-inflammatory Signaling Pathway
IL12 and Stat4 Dependent Signaling Pathway in Th1 Development
IL-2 Receptor Beta Chain in T cell Activation
IL22 Soluble Receptor Signaling Pathway
IL-7 Signal Transduction
Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
Induction of apoptosis through DR3 and DR4/5 Death Receptors
Influence of Ras and Rho proteins on G1 to S Transition
Inhibition of Cellular Proliferation by Gleevec
Inhibition of Huntington's disease neurodegeneration by histone deacetylase inhibitors
Inhibition of Matrix Metalloproteinases
Insulin Signaling Pathway
Integrin Signaling Pathway
Internal Ribosome Entry Pathway
Intrinsic Prothrombin Activation Pathway
Ion Channel and Phorbal Esters Signaling Pathway
Ion Channels and Their Functional Role in Vascular Endothelium

Keratinocyte Differentiation

Lactose Synthesis
Lck and Fyn tyrosine kinases in initiation of TCR Activation
Lectin Induced Complement Pathway
Leloir pathway of galactose metabolism
Links between Pyk2 and Map Kinases
Lissencephaly gene (LIS1) in neuronal migration and development
Low-density lipoprotein (LDL) pathway during atherogenesis

Malate-aspartate shuttle
Map Kinase Inactivation of SMRT Corepressor
MAPKinase Signaling Pathway
mCalpain and friends in Cell motility
Mechanism of Acetaminophen Activity and Toxicity
Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
Mechanisms of transcriptional repression by DNA methylation
Melanocyte Development and Pigmentation Pathway
Metabolism of Anandamide, an Endogenous Cannabinoid
METS affect on Macrophage Differentiation
Mitochondrial Carnitine Palmitoyltransferase (CPT) System
Monocyte and its Surface Molecules
Msp/Ron Receptor Signaling Pathway
mTOR Signaling Pathway
Multi-Drug Resistance Factors
Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
Multi-step Regulation of Transcription by Pitx2

Nerve growth factor pathway (NGF)
Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling
Neutrophil and Its Surface Molecules
NFAT and Hypertrophy of the heart (Transcription in the broken heart)
NFkB activation by Nontypeable Hemophilus influenzae
NF-kB Signaling Pathway
Nitric Oxide Signaling Pathway
Nitrogen-depedent regulation of Rtg1 and Rtg3 in TOR pathway
NO2-dependent IL 12 Pathway in NK cells
Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells
Nuclear Receptors in Lipid Metabolism and Toxicity

Omega Oxidation
Opposing roles of AIF in Apoptosis and Cell Survival
Overview of telomerase protein component gene hTert Transcriptional Regulation
Overview of telomerase RNA component gene hTerc Transcriptional Regulation
OX40 Signaling Pathway
Oxidation of odd-numbered chain fatty acid, from Propionyl-CoA to Succinyl-CoA
Oxidation of Polyunsaturated Fatty Acid
Oxidative reactions of the pentose phosphate pathway
Oxidative Stress Induced Gene Expression Via Nrf2

p38 MAPK Signaling Pathway
p53 Signaling Pathway
PDGF Signaling Pathway
Pelp1 Modulation of Estrogen Receptor Activity
Pertussis toxin-insensitive CCR5 Signaling in Macrophage
Phosphatidylcholine Biosynthesis Pathway
Phosphoinositides and their downstream targets.
Phospholipase C d1 in phospholipid associated cell signaling
Phospholipase C Signaling Pathway
Phospholipase C-epsilon pathway
Phospholipid Biosynthesis in E. Coli Pathway
Phospholipids as signalling intermediaries
Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway
PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
Platelet Amyloid Precursor Protein Pathway
Polyadenylation of mRNA
Presenilin action in Notch and Wnt signaling
Prion Pathway
Proepithelin Conversion to Epithelin and Wound Repair Control
Proteasome Complex
Protein Kinase A at the Centrosome
Proteolysis and Signaling Pathway of Notch
PTEN dependent cell cycle arrest and apoptosis

Rab GTPases Mark Targets In The Endocytotic Machinery
Rac 1 cell motility signaling pathway
Ras Signaling Pathway
Ras-Independent pathway in NK cell-mediated cytotoxicity
RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
Reelin Signaling Pathway
Regulation And Function Of ChREBP in Liver
Regulation of BAD phosphorylation
Regulation of cell cycle progression by Plk3
Regulation of ck1/cdk5 by type 1 glutamate receptors
Regulation of eIF2
Regulation of eIF4e and p70 S6 Kinase
Regulation of hematopoiesis by cytokines
Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases
Regulation of p27 Phosphorylation during Cell Cycle Progression
Regulation of PGC-1a
Regulation of Spermatogenesis by CREM
Regulation of Splicing through Sam68
Regulation of transcriptional activity by PML
Regulators of Bone Mineralization
Repression of Pain Sensation by the Transcriptional Regulator DREAM
Reversal of Insulin Resistance by Leptin
Rgt1 in Yeast Glucose Induction Pathway
Rho cell motility signaling pathway
Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation
RNA polymerase III transcription
Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility
Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy
Role of ERBB2 in Signal Transduction and Oncology
Role of Erk5 in Neuronal Survival
Role of MAL in Rho-Mediated Activation of SRF
Role of MEF2D in T-cell Apoptosis
Role of Mitochondria in Apoptotic Signaling
Role of nicotinic acetylcholine receptors in the regulation of apoptosis
Role of Parkin in the Ubiquitin-Proteasomal Pathway
Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration
Role of PPAR-gamma Coactivators in Obesity and Thermogenesis
Role of Ran in mitotic spindle regulation
Role of ▀-arrestins in the activation and targeting of MAP kinases
Role of Tob in T-cell activation
Roles of ▀-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling

Segmentation Clock
Selective expression of chemokine receptors during T-cell polarization
Shuttle for transfer of acetyl groups from mitochondria to the cytosol
Signal Dependent Regulation of Myogenesis by Corepressor MITR
Signal transduction through IL1R
Signaling of Hepatocyte Growth Factor Receptor
Signaling Pathway from G-Protein Families
Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
Small Leucine-rich Proteoglycan (SLRP) molecules
Snf1 in Yeast Glucose Repression/Derepression
SODD/TNFR1 Signaling Pathway
Sonic Hedgehog (Shh) Pathway
Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle
Spliceosomal Assembly
Sprouty regulation of tyrosine kinase signals
SREBP control of lipid synthesis

▀-arrestins in GPCR Desensitization

Starch Synthesis
Stat3 Signaling Pathway
Stathmin and breast cancer resistance to antimicrotubule agents
Steps in the Glycosylation of Mammalian N-linked Oligosaccarides
Stress Induction of HSP Regulation
Sucrose Synthesis
SUMOylation as a mechanism to modulate CtBP-dependent gene responses
Sumoylation by RanBP2 Regulates Transcriptional Repression
Synaptic Proteins at the Synaptic Junction
Synthesis of Cardiolipin & phosphatidylinositol
Synthesis of plasmalogens

T Cell Receptor and CD3 Complex
T Cell Receptor Signaling Pathway
T Cytotoxic Cell Surface Molecules
T Helper Cell Surface Molecules
TACI and BCMA stimulation of B cell immune responses.
Telomeres, Telomerase, Cellular Aging, and Immortality
TGF beta signaling pathway
Th1/Th2 Differentiation
The 4-1BB-dependent immune response
The Citric Acid Cycle
The Co-Stimulatory Signal During T-cell Activation
The IGF-1 Receptor and Longevity
The information-processing pathway at the IFN-beta enhancer
The PRC2 Complex Sets Long ľterm Gene Silencing Through Modification of Histone Tails
The reactions that feed amino groups into the urea cycle
The Role of Eosinophils in the Chemokine Network of Allergy
The role of FYVE-finger proteins in vesicle transport
The salvage pathway from serine to phosphatidylcholine
The SARS-coronavirus Life Cycle
Thrombin signaling and protease-activated receptors
TNF/Stress Related Signaling
TNFR1 Signaling Pathway
TNFR2 Signaling Pathway
Toll-Like Receptor Pathway
TPO Signaling Pathway
Transcription factor CREB and its extracellular signals
Transcription Regulation by Methyltransferase of CARM1
Transcriptional activation of dbpb from mRNA
Trefoil Factors Initiate Mucosal Healing
Trka Receptor Signaling Pathway
TSP-1 Induced Apoptosis in Microvascular Endothelial Cell
Tumor Suppressor Arf Inhibits Ribosomal Biogenesis

uCalpain and friends in Cell spread

VEGF, Hypoxia, and Angiogenesis
Visceral Fat Deposits and the Metabolic Syndrome
Visual Signal Transduction
Vitamin C in the Brain

West Nile Virus
WNT Signaling Pathway
Wnt/LRP6 Signalling

Y branching of actin filaments
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