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The estrogen-inducible RING finger protein Efp stimulates proliferation of breast cancer cells. 14-3-3 is p53-inducible protein that sequesters mitotic Cdks in the cytoplasm to inhibit entry into mitosis. To allow cell-cycle progression, estrogens stimulate production of Efp, which binds and ubiquinates 14-3-3s sigma. 14-3-3s marked with ubiquitin chains is recognized and destroyed by the proteosome. Released Cdks are now free to escape into the nucleus and promote mitotic entry. |
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Kosi Gramatikoff, PhD |
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Akira Orimo, Satoshi Inoue, Kazuhiro Ikeda, Sumihare Noji, and Masami Muramatsu Molecular Cloning, Structure, and Expression of Mouse Estrogen-responsive Finger Protein Efp J. Biol. Chem., Oct 1995; 270: 24406 - 24413.
K Ikeda, A Orimo, Y Higashi, M Muramatsu, and S Inoue Efp as a primary estrogen-responsive gene in human breast cancer. FEBS Lett, Apr 2000; 472(1): 9-13.
T Urano, T Saito, T Tsukui, M Fujita, T Hosoi, M Muramatsu, Y Ouchi, and S Inoue Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. Nature, Jun 2002; 417(6891): 871-5.
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