:: ATP-binding cassette sub-family B (MDR/TAP) member 6 (ABCB6) polyclonal antibody

ATP-binding cassette sub-family B (MDR/TAP) member 6 (ABCB6) polyclonal antibody

Animal ID:
RB1809-1810

Host:
Rabbit

Reactivity:
Human

Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.

Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.

Application:
Tested by peptide-specific ELISA (1:1,000). WB (1:100 ~1:500), IHC (1:50 ~1:100)

Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 827 - 842 [GQEETSEDTKPQTMER] of the human ATP-binding cassette sub-family B (MDR/TAP) member 6 (ABCB6) protein.

Accession number:
NM_005689

Description:
The ATP-binding cassette sub-family B (MDR/TAP) member 6 (ABCB6) protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) and ABCB6 is a member of the MDR/TAP subfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes and members of the MDR/TAP subfamily are involved in multidrug resistance, lipid transportation as well as antigen presentation. ABCB6 encodes a half-transporter which likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. ABCB6 has a strong similarity to rat UMAT and is overexpressed during hepatocarcinogenesis.

Alternative Name(s):
ATP-binding cassette sub-family B (MDR/TAP) member 6, umat, ABC14, MTABC3, EST45597, ABCB6

References:

Mitsuhashi N, Miki T, Senbongi H, Yokoi N, Yano H, Miyazaki M, Nakajima N, Iwanaga T, Yokoyama Y, Shibata T, Seino S: MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis. J. Biol. Chem. 275(23): 17536-17540 (2000).
Furuya KN, Bradley G, Sun D, Schuetz EG, Schuetz JD: Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis. Cancer Res. 57(17): 3708-3716 (1997).

For Research Use Only. Not for Diagnostic or Therapeutic Use.